Robust response-guided dosing

Genotype-guided dosing of warfarin.

Vitamin K antagonists (VKAs) have been used to treat thromboembolic disease for over 60 years, and they continue to be the most commonly prescribed anticoagulants worldwide. However, VKAs such as warfarin have a narrow therapeutic index, and the mean daily dose of warfarin varies widely from patient to patient. Underdosing can leave patients undertreated for their thromboembolic diseases; overd...

Genotype-guided dosing of vitamin K antagonists.

To the Editor: Three articles in the December 12 issue1-3 address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know whether the authors stratified patients by age and whether coexisting con...

DNA-guided Warfarin Dosing Algorithm Protocol

Robust Guided Image Filtering

The process of using one image to guide the filtering process of another one is called Guided Image Filtering (GIF). The main challenge of GIF is the structure inconsistency between the guidance image and the target image. Besides, noise in the target image is also a challenging issue especially when it is heavy. In this paper, we propose a general framework for Robust Guided Image Filtering (R...

Guided medication dosing for inpatients with renal insufficiency.

CONTEXT Usual drug-prescribing practices may not consider the effects of renal insufficiency on the disposition of certain drugs. Decision aids may help optimize prescribing behavior and reduce medical error. OBJECTIVE To determine if a system application for adjusting drug dose and frequency in patients with renal insufficiency, when merged with a computerized order entry system, improves dr...